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Publication: Metabolism and disposition of ataluren after oral administration to mice, rats, dogs, and humans

This research article, published in Drug Metabolism and Disposition, looks at the in vivo metabolism of ataluren in selected species 

  • The metabolism of ataluren, a novel carboxylic acid–containing small molecule drug used for the treatment of diseases resulting from nonsense mutation Duchenne muscular dystrophy (nmDMD), is discussed
  • Absorption and disposition in vivo data from investigations in mice, rats, dogs, and healthy humans are presented
  • The mechanisms for ataluren metabolism are outlined

Kong R, Ma J, Hwang S, et al. Drug Metab Dispos. 2020;48:317–325 

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