ASCO 2017 poster: Phase 1b results of PTC596, a novel small molecule targeting cancer stem cells (CSCs) by reducing levels of BMI1 protein

Data from a Phase 1b dose-escalation study of PTC596 to treat patients with a variety of solid tumors are reported in our poster presented at the 2017 American Society of Clinical Oncology (ASCO) meeting, held in Chicago 

  • Results from a Phase 1b study investigating PTC596 – a therapy under investigation for its role in reducing levels of tumor CSCs through regulation of the BMI1 protein – are presented
  • The pharmacodynamics, safety and tolerability, and disease progression, which were evaluated in 31 patients treated with PTC596, along with changes in levels of polymorphonuclear leukocytes, are discussed
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