ESMO 2016 poster: First-in-human Phase 1 results of PTC596, a novel small molecule that targets cancer stem cells (CSCs) by reducing BMI1 protein levels

This poster presentation, from the 2016 European Society for Medical Oncology (ESMO) Conference in Copenhagen, discusses the results of our Phase 1 clinical trial to study pharmacokinetics and tolerability of PTC596 in humans 

  • The details of a Phase 1 dose-escalation study, investigating the pharmacokinetics and safety of PTC596, a novel agent which reduces levels of the BMI1 protein and inhibits survival of CSCs, are presented
  • Safety and tolerability results are discussed, alongside the pharmacokinetic profile of PTC596 at different doses in 25 patients with a range of advanced solid tumors
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MED-ALL-UNSBN-2100001 | October 2021
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