Publication: Unesbulin: A novel anti-tubulin cancer therapeutic

This research article, published in the Journal of Clinical Haematologyreports on the pharmacokinetic properties of unesbulin (PTC596), including safety and tolerability data, based on results of a Phase I, first-in-human study 

  • Unesbulin is a novel molecule being investigated for the treatment of cancer because of its ability to reduce levels of the BMI1 protein, which prevents the survival of cancer stem cells
  • An overview of the mechanism of action of unesbulin and a comparison with properties of other anti-tubulin agents are presented
  • Results from a Phase I dose-escalation study of unesbulin in 31 patients with advanced solid tumors are discussed

Gao L, Weetall M, O’Keefe K, et al. J Clin Haematol. 2021;2(3):80–85 

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