EHA 2019 Abstract: Inhibition of de novo pyrimidine nucleotide synthesis by the novel dihydroorotate dehydrogenase (DHODH) inhibitor PTC299 induces differentiation and/or death of acute myeloid leukemia (AML) cells

This abstract, presented at the 2019 EHA Congressreports on the effects of treatment with a novel DHODH inhibitor under investigation as a potential treatment for AML on cell lines in vitro 

  • Activity of a DHODH inhibitor against specific leukemia and lymphoma cell lines is described, and the effects on proliferation and differentiation on cells are discussed
  • The impact on the pyrimidine nucleotide synthesis pathway is reported
  • Effects of the agent on both wild-type p53 and p53-deficient leukemia cells are described
Register now to unlock the content

Register now to access the content on this page

Already registered?
If not, register below

  • This Website is intended only for healthcare professionals (“Website“), is operated by PTC Therapeutics. (together with its affiliates “PTC”). In order to access the restricted content on this Website:

  • PTC will delete immediately the information provided if we cannot confirm you are healthcare professional.
    Otherwise, in case of successful verification, PTC will retain the information provided for a period of two (2) years two (2) years following your registration (i) only for the purposes of providing you access to this Website; and/or (ii) in case you signed up to receive PTC updates.

Providing your personal data and your consent is voluntary, and you have the right to withdraw your consent at any time, without giving any reasons. Please consult our Privacy Statement for more information on the processing of your personal data.
For any enquiry relating to the processing of your personal data or if you want to exercise your privacy related rights or withdraw your consent, you can contact PTC’s Privacy Office at:

You can unsubscribe from updates at any time when receiving an email from PTC.

MED-ALL-AML-2100043 | October 2021
Sign in or register to access exclusive content on this site 

Welcome to MEDhub

A website for healthcare professionals, provided by PTC Therapeutics

This educational website provides you with the latest scientific data and expert
insights on the diagnosis and management of a range of rare diseases across the neuromuscular system, central nervous system, and other areas

This content is protected. To view it please enter your email address below:

Register here to access the content on the site
GL-CORP-0207 | June 2021


The content you are trying to access is not currently available.

We will be updating the MEDhub site regularly to provide you with up-to-date, insightful expert-led content. To be notified when new additions become available, register now.