ICAR 2021 Poster: The dihydroorotate dehydrogenase (DHODH) inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines implicated in COVID-19 disease and is currently being evaluated in the FITE19 clinical trial in hospitalized patients

This poster, presented at the 2021 ICAR virtual meeting, shows results from experiments to investigate a novel DHODH inhibitor as a potential treatment for COVID-19 

  • Preclinical data from cell culture experiments to determine the mechanism of action of an orally available DHODH inhibitor are shown
  • Potency of the agent is compared with other DHODH inhibitors
  • Rationale and study design for a Phase 2/3 clinical trial to investigate the molecule in patients with COVID-19 is presented
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MED-ALL-COVID-2100026 | October 2021
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