Publication: Dual mechanism of action of PTC299 and other dihydroorotate dehydrogenase (DHODH) inhibitors in suppressing SARS-CoV-2 replication and cellular cytokine storms

This research article, published in the Journal of Cytokine Biologyreports on the mechanism by which a novel DHODH inhibitor prevents SARS-CoV-2 viral replication 

  • Results from the in vitro analyses of activity of this orally bioavailable agent on viral replication of SARS-CoV-2 are discussed
  • Effects of the DHODH inhibitor on production of inflammatory mediators by human cells are reported
  • Combining these results, a dual mechanism of action is presented, for the potential treatment of patients with COVID-19

Goodwin E, Jacobson A, Weetall M, et al. J Cytokine Biol. 2021;6:3   

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