Publication: First-in-human studies of pharmacokinetics and safety of utreloxastat (PTC857), a novel 15-lipooxygenase inhibitor for the treatment of amyotrophic lateral sclerosis
This first-in-human double-blind, placebo-controlled trial, published in Clinical Pharmacology in Drug Development, investigates the safety and pharmacokinetics (PK) of utreloxastat in healthy participants for the potential treatment of amyotrophic lateral sclerosis (ALS)
Learn more about ALS, a progressive, rare neurodegenerative genetic disease
Review the patient characteristics and the study protocol
Review the development of utreloxastat, an investigational compound targeting 15-lipoxygenase (15-LO) in the treatment for ALS
Learn about the initial safety findings and pharmacokinetics of utreloxastat from a phase 1 healthy volunteer study
Gao L, Giannousis P, Thoolen M, et al. Clin Pharmacol Drug Dev. 2023;12(2):141–151
Utreloxastat is an investigational drug currently in development for ALS.
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MED-ALL-ALS-2300001 | February 2024
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