DDW 2020 abstract: Improved gastric accommodation in women with moderate or severe diabetic gastroparesis randomized to oral CNSA-001 (sepiapterin) versus placebo 

This abstract, presented at the DDW meeting 2020, reports the results of a trial investigating use of CNSA-001 as a regulator of circulating BH4 levels to treat diabetic gastroparesis. 

  • The results from a Phase 2 trial involving 21 women with diabetic gastroparesis  who were randomized to receive CNSA-001 or placebo  are presented in this abstract 
  • Gastric accommodation was measured over 28 days’ treatment. Symptom severity scales and the Gastric Emptying Breath Test (GEBT) were also employed as outcome measures. Adverse events associated with treatment are reported. 
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