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Home | Metabolism | Phenylketonuria (PKU) | Congress activities | The International Congress of Inborn Errors of Metabolism (ICIEM) | ICIEM 2025 oral presentation: AMPLIPHY: A phase 3 study comparing the efficacy and safety of sepiapterin and sapropterin in children and adults with phenylketonuria

ICIEM 2025 oral presentation: AMPLIPHY: A phase 3 study comparing the efficacy and safety of sepiapterin and sapropterin in children and adults with phenylketonuria

This ICIEM 2025 oral presentation provides an overview of the AMPLIPHY phase 3 study which compares the efficacy and safety of sepiapterin and sapropterin in children and adults with phenylketonuria (PKU)

  • Learn more about more about the unmet need in PKU and the AMPLIPHY study
  • Understand the effectiveness of sepiapterin vs sapropterin in this global, phase 3, two-part, randomized, crossover, open-label, active-controlled study
  • Gain an overview of the safety profile of sepiapterin and sapropterin in this study
▼ Sepiapterin is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system. Adverse events should also be reported to PTC Therapeutics at pharmacovigilance@ptcbio.com.

Registration conditions differ internationally; always consult local prescribing information and/or Summary of Product Characteristics before prescribing any products.

MED-ALL-PTC923-2500012 | September 2025

This symposium was developed and funded by PTC Therapeutics for ICIEM 2025.

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