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Home | Metabolism | Phenylketonuria (PKU) | Congress activities | The Society for the Study of Inborn Errors of Metabolism (SSIEM) | SSIEM 2026 poster: Improved efficacy with sepiapterin in participants with PKU receiving sapropterin at study screening in AMPLIPHY

SSIEM 2026 poster: Improved efficacy with sepiapterin in participants with PKU receiving sapropterin at study screening in AMPLIPHY

This poster, presented at SSIEM 2026, highlights the efficacy and safety of sepiapterin in participants with phenylketonuria (PKU) who were already receiving sapropterin at study screening in the AMPLIPHY Phase 3 study

  • Learn about the efficacy of sepiapterin treatment in people with PKU who were previously receiving sapropterin
  • Understand the role of sepiapterin in achieving clinically relevant blood Phe targets in people with PKU, and its potential to support greater dietary flexibility
  • Review safety and tolerability findings from the AMPLIPHY study, including treatment-emergent adverse events and the overall safety profile of sepiapterin compared with sapropterin
▼ Sepiapterin is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system. Adverse events should also be reported to PTC Therapeutics at pharmacovigilance@ptcbio.com.

Registration conditions differ internationally; always consult local prescribing information and/or Summary of Product Characteristics before prescribing any products.

MED-ALL-PTC923-2500012 | September 2025

​​This poster was developed and funded by PTC Therapeutics for SSIEM.

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MED-ALL-PKU-2600168 | September 2026

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