Publication: Effects of oral sepiapterin on blood Phe concentration in a broad range of patients with phenylketonuria (APHENITY): Results of an international, phase 3, randomised, double-blind, placebo-controlled trial
Published in The Lancet 2024, this research article presents findings from APHENITY, a Phase 3 clinical trial evaluating the efficacy and safety of sepiapterin in patients with phenylketonuria (PKU)
- Understand the clinical efficacy of sepiapterin in patients with PKU
- Review the effect of sepiapterin on blood phenylalanine (Phe) in participants who completed the Phase 3 APHENITY trial
- Learn more about the safety profile of sepiapterin in this study
Registration conditions differ internationally; always consult local prescribing information and/or Summary of Product Characteristics before prescribing any products.
MED-ALL-PTC923-2500012 | September 2025
Muntau A, Longo N, Ezgu F, et al. Lancet 2024; 404:1333–45
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