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Home | Metabolism | Phenylketonuria (PKU) | Publications | Publication: Ethnic bridging of sepiapterin in Chinese and Korean populations based on predictions from genetic polymorphism of breast cancer resistance protein

Publication: Ethnic bridging of sepiapterin in Chinese and Korean populations based on predictions from genetic polymorphism of breast cancer resistance protein

This research article explores the ethnic pharmacokinetic bridging of sepiapterin between Chinese and Korean populations using predictions based on genetic polymorphisms of the breast cancer resistance protein (BCRP), with relevance to its development as a therapy for phenylketonuria (PKU)

  • Understand how genetic variation in BCRP may influence sepiapterin exposure across Asian populations
  • Assess the rationale for ethnic bridging studies in supporting global development of sepiapterin for PKU
  • Gain insight into pharmacogenetic considerations when translating dosing and exposure data between populations
▼ Sepiapterin is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system. Adverse events should also be reported to PTC Therapeutics at pharmacovigilance@ptcbio.com.

Registration conditions differ internationally; always consult local prescribing information and/or Summary of Product Characteristics before prescribing any products.

MED-ALL-PTC923-2500012 | September 2025

Gao L, Smith N, Kong R. Clin Transl Sci. 2026 Apr;19(4):e70549.

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MED-ALL-PKU-2600103 | May 2026

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