Publication: Metabolite V, an epoxide species, is a minor circulating metabolite in humans following a single oral dose of deflazacort

This research article, published in Pharmacology Research & Perspectives, investigates the plasma pharmacokinetics, metabolite profiles and their quantitative exposures in humans following a single oral dose of deflazacort 

  • Human circulating metabolites of deflazacort following a single oral dose are presented
  • The influence of a single dose of oral deflazacort is discussed
  • Safety findings following a single oral dose of deflazacort are presented

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Kong R, Ma J, Beers B, et al.  Pharmacol Res Perspect. 2020;8(6):e00677 

Deflazacort is a corticosteroid indicated for the treatment of Duchenne muscular dystrophy (DMD) in patients 2 years of age and older. PTC Therapeutics is the Marketing Authorization Holder for deflazacort in the US only. Registration conditions differ internationally, and prescribing information may vary depending on local approval in each country. The US Prescribing Information for deflazacort is available here. Please refer to your local country guidance for more information. 

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