Publication: Ataluren metabolism: Ataluren-O-1β-acyl glucuronide is a stable circulating metabolite in mice, rats, dog and human

This research article, published in Drug Metabolism and Pharmacokinetics, evaluates the in vitro and in vivo stability of ataluren-O-1β-acyl glucuronide metabolite 

  • The safety profile of ataluren acyl glucuronide is presented
  • The in vitro and in vivo stability of ataluren acyl glucuronide in mice, rat, dog and human patients is discussed
  • Safety outcomes relating to ataluren-O-1β-acyl glucuronide are presented

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Ma J, Risher N, Northcutt V, et al. Drug Metab Pharmacokinet. 2021;38:100393 

▼ Ataluren is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system. Adverse events should also be reported to PTC at pharmacovigilance@ptcbio.com.

Registration conditions differ internationally, and prescribing information may vary depending on local approval in each country. The European Summary of Product Characteristics for ataluren is available here. Please refer to your local country guidance for more information.

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