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Home | Neuromuscular | Duchenne muscular dystrophy (DMD) | Publications | Publication: Metabolism and disposition of ataluren after oral administration to mice, rats, dogs, and humans

Publication: Metabolism and disposition of ataluren after oral administration to mice, rats, dogs, and humans

This research article, published in Drug Metabolism and Disposition, looks at the in vivo metabolism of ataluren in selected species

  • The metabolism of ataluren, a novel carboxylic acid–containing small molecule drug used for the treatment of diseases resulting from nonsense mutation Duchenne muscular dystrophy (nmDMD), is discussed
  • Absorption and disposition in vivo data from investigations in mice, rats, dogs, and healthy humans are presented
  • The mechanisms for ataluren metabolism are outlined
▼ Ataluren is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system. Adverse events should also be reported to PTC Therapeutics at pharmacovigilance@ptcbio.com.

Registration conditions differ internationally; always consult local prescribing information and/or Summary of Product Characteristics before prescribing any products.

MED-ALL-ATLN-2500006 | September 2025

Kong R, Ma J, Hwang S, et al. Drug Metab Dispos. 2020;48:317–325

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MED-ALL-DMD-2300008 | June 2025

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