Publication: Pharmacokinetics and safety of PTC596, a novel tubulin-binding agent, in subjects with advanced solid tumors

This research article, published in Clinical Pharmacology in Drug Developmentreports the results of a Phase 1 dose-escalation study of PTC596, a novel, orally-administered molecule, being investigated for treatment of solid tumors 

  • Pharmacokinetic data, including bioavailability, absorption, accumulation, and excretion values, for PTC596 given at different doses to human subjects, is provided. Data includes bioavailability and absorption area under the curve
  • Analysis of adverse effects in patients with a range of solid tumors, along with best overall tumor response to treatment with PTC596 up to 16 weeks, is discussed

Shapiro GI, O’Mara E, Laskin OLet al. Clin Pharmacol Drug Dev. 2021. Published online ahead of print 

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